The San Francisco 49ers are facing the Indianapolis Colts at Lucas Oil Stadium in Week 16. Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available.
Players are listed in order of most recent report.
LB Tatum Bethune (ankle, questionable)
Tatum Bethune remained down on the field late in the third quarter but eventually got up and jogged off. Eric Kendricks replaced Bethune at the MIKE linebacker spot.
The 49ers announced Bethune is questionable to return due to an ankle injury.
#49ers @DignityHealth Injury Update: Tatum Bethune is questionable to return (ankle).
— San Francisco 49ers (@49ers) December 23, 2025
TE George Kittle (ankle, questionable)
George Kittle did not appear comfortable after coming off the field in the third quarter. He was later seen pacing on the sideline as he tested his legs.
The ESPN broadcast announced that Kittle is questionable to return due to an ankle injury. The tight end exited the game with seven catches for 115 yards and a touchdown on eight targets.
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