Kittle was carted off the field in the second quarter and taken to the locker room for evaluation, and the team soon confirmed what many feared.
George Kittle was ruled out with an Achilles injury.
NBC Sports Bay Area's Matt Maiocco noted that recovery from a torn Achilles typically takes nine to 12 months, a timeline that places Kittle's availability for the 2026 season in serious doubt.
The injury marks another devastating blow for the 49ers, who have already lost cornerstone players such as linebacker Fred Warner and defensive end Nick Bosa for the season. Still, the team fought to a 12-5 regular-season record, earning a playoff berth.
Despite the mounting adversity, San Francisco continues to battle the Philadelphia Eagles in a Wild Card playoff game at Lincoln Financial Field. As of halftime, the 49ers trail 13-10. Kittle finished with one catch for six yards before exiting, and now the 49ers must find a way to win without one of the emotional leaders of their offense.